Regulation of the mitochondrial tricarboxylic acid cycle

Tricarboxylic Acid Cycle in

The Tricarboxylic Acid Cycle in Dictyostelium discoideum

Some aspects of tricarboxylic acid-cycle activity during differentiation and aging in Dictyostelium discoideum were examined. The concentrations of glutamate, aspartate, alanine, citrate, 2-oxoglutarate, succinate, fumarate, malate, oxaloacetate, pyruvate and acetyl-CoA were determined at four stages over the course of differentiation. The rate of 02 utilization was also determined over differe...

The Tricarboxylic Acid Cycle in Dictyostelium discoideum

Experimental studies of enzyme kinetics in vitro and metabolic fluxes in vivo have been used by Wright and her colleagues to develop a detailed kinetic model of the tricarboxylic acid cycle in Dictyostelium discoideum. This model has recently been been analyzed by two different methods (Albe, K. R., and Wright, B. E. (1992) J. Biol. Chem. 267, 3106-3114; Shiraishi, F., and Savageau, M. A. (199...

The Tricarboxylic Acid Cycle in Rhodospirillum Rubrum

The oxidation of acetic acid in the dark by the non-sulfur purple bacterium, Rhodospirillum rubrum, was shown by van Niel (1, 2) to require the presence of either carbon dioxide or trace amounts of the Cb-dicarboxylic acids of the Krebs cycle. These results could readily be interpreted to mean that the oxidation of acetic acid proceeds by way of the Krebs cycle, the presence of COZ being requir...

The mechanism of tricarboxylic acid cycle regulation of fatty acid synthesis.

Reaction 1, the carboxylation of acety-CoA to form malonylCo& is catalyzed by acetyl-CoA carboxylase, a biotin enzyme (l-6). Reaction 2, the reaction of acetyl-CoA with 7 moles of malonyl-CoA and 14 moles of TPNH to form palmitate, is an incompletely understood complex reaction catalyzed by palmitate synthetase (7-10). In recent years, there has been a number of observations (11-13) demonstrati...